{"id":2126,"date":"2024-07-26T11:56:46","date_gmt":"2024-07-26T03:56:46","guid":{"rendered":"https:\/\/aimedorig.com\/wordpress\/?p=2126"},"modified":"2024-07-26T12:00:52","modified_gmt":"2024-07-26T04:00:52","slug":"%e4%b8%8a%e6%b5%b7%e4%ba%a4%e5%a4%a7%e9%99%88%e6%b5%b7%e5%b3%b0%e8%af%be%e9%a2%98%e7%bb%84%e5%9c%a8rna%e5%88%86%e5%ad%90%e5%8a%9b%e5%9c%ba%e7%a0%94%e7%a9%b6%e4%b8%ad%e5%8f%96%e5%be%97%e9%87%8d","status":"publish","type":"post","link":"https:\/\/aimedorig.com\/wordpress\/?p=2126","title":{"rendered":"\u4e0a\u6d77\u4ea4\u5927\u9648\u6d77\u5cf0\u8bfe\u9898\u7ec4\u5728RNA\u5206\u5b50\u529b\u573a\u7814\u7a76\u4e2d\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2126\" class=\"elementor elementor-2126\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb1e348 e-flex e-con-boxed e-con e-parent\" data-id=\"cb1e348\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-60b5fd1 elementor-widget elementor-widget-text-editor\" data-id=\"60b5fd1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 25-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>\u8fd1\u65e5\uff0c\u516c\u53f8\u521b\u59cb\u4eba<strong>\u9648\u6d77\u5cf0\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\u5728\u300a<strong>J. Chem. Theory Comput.<\/strong>\u300b\u5728\u7ebf\u53d1\u8868\u540d\u4e3a\u201d<strong>Excited-Ground State Transition of RNA Strand Slippage Mechanism Captured by Base-specific Force Field<\/strong>\u201c\u7684\u7814\u7a76\u6210\u679c\uff0c\u8be5\u7814\u7a76\u4e3a\u4e2a\u6027\u5316\u7cbe\u51c6RNA\u5206\u5b50\u529b\u573a\u5f00\u53d1\u53caRNA\u52a8\u6001\u6784\u8c61\u8f6c\u6362\u673a\u5236\u63d0\u51fa\u4e86\u91cd\u8981\u53c2\u8003\u3002\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u751f\u547d\u79d1\u5b66\u6280\u672f\u5b66\u9662\u535a\u58eb\u751f<span class=\"wx_search_keyword_wrap\">\u674e\u653f\u65b0<i class=\"wx_search_keyword\"><\/i><\/span>\u4e0e\u672c\u79d1\u751f\u5b8b\u6b4c\u3001\u6731\u9a8f\u6770\u4e3a\u6587\u7ae0\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u751f\u547d\u79d1\u5b66\u6280\u672f\u5b66\u9662<strong>\u9648\u6d77\u5cf0<\/strong><strong>\u6559\u6388<\/strong>\u4e3a\u901a\u8baf\u4f5c\u8005\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u751f\u547d\u79d1\u5b66\u6280\u672f\u5b66\u9662\u751f\u7269\u4fe1\u606f\u5b66\u4e0e\u751f\u7269\u7edf\u8ba1\u5b66\u7cfb\u4e3a\u8be5\u6587\u7ae0\u7b2c\u4e00\u901a\u8baf\u5355\u4f4d\u3002<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-2128\" src=\"https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115552.png\" alt=\"\" width=\"800\" height=\"398\" srcset=\"https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115552.png 800w, https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115552-300x149.png 300w, https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115552-768x382.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p><p>\u56fe1. AU\u3001GC\u6c83\u68ee-\u514b\u91cc\u514b\u914d\u5bf9\u53caGU\u975e\u6c83\u68ee-\u514b\u91cc\u514b\u914d\u5bf9\u7684\u80fd\u91cf\u626b\u63cf\u53ca\u6821\u6b63<\/p><p>RNA\u52a8\u6001\u6784\u8c61\u7cfb\u7efc\u662f\u5176\u53d1\u6325\u8f6c\u5f55\u3001\u7ffb\u8bd1\u3001\u50ac\u5316\u7b49\u591a\u79cd\u591a\u6837\u7684\u751f\u7406\u529f\u80fd\u7684\u57fa\u7840\uff0c\u5f53\u524d\u5b9e\u9a8c\u65b9\u6cd5\u96be\u4ee5\u7cbe\u51c6\u89e3\u6790\uff0c\u56e0\u6b64\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u6210\u4e3a\u4e86\u91cd\u8981\u7814\u7a76\u624b\u6bb5\u3002<span class=\"wx_search_keyword_wrap\">\u5206\u5b50\u529b\u573a<i class=\"wx_search_keyword\"><\/i><\/span>\u51b3\u5b9a\u4e86\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u7684\u7cbe\u5ea6\uff0c\u7136\u800c\u73b0\u6709RNA\u5206\u5b50\u529b\u573a\u5b58\u5728\u8bf8\u591a\u4e0d\u8db3\u3002\u6b64\u524d\u9648\u6d77\u5cf0\u8bfe\u9898\u7ec4\u5df2\u5f00\u53d1\u591a\u79cd\u6539\u8fdbRNA\u5206\u5b50\u529b\u573a\uff0c\u672c\u6b21\u7814\u7a76\u63d0\u51fa\u7684BSFF2\u662f\u5728\u6b64\u524dBSFF1\u7814\u7a76\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u4f18\u5316\u4e3b\u94fe\u7ed3\u6784\u540c\u65f6\u5f15\u5165\u4e8c\u7ea7\u7ed3\u6784\u914d\u5bf9\u80fd\u91cf\u6821\u6b63\u9879\uff08\u56fe1\uff09\uff0c\u4ece\u800c\u66f4\u4e3a\u7cbe\u51c6\u7684\u6355\u83b7RNA\u52a8\u6001\u6784\u8c61\u4fe1\u606f\u3002<\/p><p>\u7ecf\u8fc7\u9a8c\u8bc1\uff0cBSFF2\u529b\u573a\u80fd\u591f\u7cbe\u786e\u6a21\u62df\u56db\u6838\u82f7\u9178\u3001\u77ed\u5355\u94fe\u3001\u53cc\u94fe\u3001\u7a81\u8d77\u7b49\u591a\u79cd\u5e38\u89c1RNA motif\u4f53\u7cfb\uff0c\u540c\u65f6\u5728tetraloop\u4ece\u5934\u6298\u53e0\u3001\u78b1\u57fa\u914d\u5bf9\u91cd\u7ec4\u3001\u94fe\u6ed1\u52a8\u7b49\u6a21\u62df\u4e0a\u5c55\u73b0\u4e86\u6781\u9ad8\u6548\u7387\uff0c\u80fd\u591f\u6355\u83b7r(G4C2)\u91cd\u590d\u5143\u4ef6\u7684\u94fe\u6ed1\u52a8\u5206\u5b50\u7ec6\u8282\u53ca\u5176\u673a\u5236\uff08\u56fe2\uff09\uff0c\u4e3a\u89e3\u6790\u4e0e\u4e4b\u5bc6\u5207\u76f8\u5173\u7684<span class=\"wx_search_keyword_wrap\">\u6e10\u51bb\u75c7<i class=\"wx_search_keyword\"><\/i><\/span>\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u6709\u6548\u7814\u7a76\u624b\u6bb5\uff0c\u5bf9\u4e8e\u9776\u5411RNA\u836f\u7269\u53caRNA\u7597\u6cd5\u5f00\u53d1\u5177\u5907\u91cd\u8981\u7814\u7a76\u4ef7\u503c\u3002<\/p><p><img decoding=\"async\" class=\"alignnone size-full wp-image-2129\" src=\"https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115808.png\" alt=\"\" width=\"800\" height=\"477\" srcset=\"https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115808.png 800w, https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115808-300x179.png 300w, https:\/\/aimedorig.com\/wordpress\/wp-content\/uploads\/2024\/07\/\u56fe\u7247_20240726115808-768x458.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p><p>\u56fe2. BSFF2\u529b\u573a\u6a21\u62df\u6355\u83b7r(G4C2)\u91cd\u590d\u5143\u4ef6\u7684\u94fe\u6ed1\u52a8<\/p><section>\u8be5\u7814\u7a76\u83b7\u5f97\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u8d85\u7b97\u4e2d\u5fc3\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9762\u4e0a\u9879\u76ee\uff0821977068 \u548c32171242\uff09\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\uff082023YFF1205102\u548c2020YFA0907700\uff09\u3001\u4e2d\u592e\u9ad8\u6821\u57fa\u672c\u79d1\u7814\u4e1a\u52a1\u8d39\u4e13\u9879\u8d44\u91d1\uff08YG2023LC03\uff09\u4ee5\u53ca\u798f\u5dde\u5927\u5b66\u8d35\u91cd\u4eea\u5668\u8bbe\u5907\u5f00\u653e\u6d4b\u8bd5\u57fa\u91d1\uff082024T022\uff09\u8d44\u52a9\u3002<\/section><section><\/section><section>\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/10.1021\/acs.jctc.4c00497<\/section>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u65e5\uff0c\u516c\u53f8\u521b\u59cb\u4eba\u9648\u6d77\u5cf0\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u300aJ. Chem. Theory Comput.\u300b\u5728\u7ebf\u53d1\u8868\u540d\u4e3a\u201dExcite [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[32],"tags":[],"class_list":["post-2126","post","type-post","status-publish","format-standard","hentry","category--zh"],"blocksy_meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2126"}],"collection":[{"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2126"}],"version-history":[{"count":4,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2126\/revisions"}],"predecessor-version":[{"id":2132,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2126\/revisions\/2132"}],"wp:attachment":[{"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aimedorig.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}